John F. Kennedy International Airport: For Hell’s Kitchen, skip an airport car unless you are three or more people with heavy luggage. Take the AirTrain to Howard Beach, then the A train to 42 St–Port Authority; it is direct to the neighborhood’s east edge, about 70–90 minutes and roughly $12 total. The yellow-taxi Manhattan flat fare is sensible only when splitting it; expect tolls, surcharges and tip on top, and traffic can make it no faster.
LaGuardia Airport: Take the free Q70 LaGuardia Link bus from Terminals B or C to Jackson Heights–Roosevelt Av/74 St, then the E train to 50 St (or the 7 to Times Sq). Allow 45–60 minutes; the subway portion is about $2.90. This is cheaper and often more predictable than a taxi in Midtown traffic.
Newark Liberty International Airport: Take AirTrain Newark to Newark Airport Rail Station, then NJ Transit to New York Penn Station. From Penn, Hell’s Kitchen is a 10–25 minute walk west/north or a short ride on the 1/2/3 or A/C/E. Allow 45–60 minutes in total and about $17; leave more time late at night, when rail frequencies thin out.
Penn Station / Moynihan Train Hall: This is the useful rail arrival point: Amtrak, NJ Transit and the Long Island Rail Road arrive here, beneath/alongside Madison Square Garden. Southern Hell’s Kitchen is walkable in 10–20 minutes; for 42nd–59th Streets, use the 1/2/3 or A/C/E from nearby stations rather than taking a cab through Midtown.
Grand Central Terminal: Take the 42 St Shuttle (S) or the 7 to Times Sq–42 St, then walk west into Hell’s Kitchen; 15–30 minutes door to door and one subway fare (about $2.90). A taxi for this short cross-Manhattan trip is usually slower in daytime traffic.
Port Authority Bus Terminal: It sits at Eighth Avenue between 40th and 42nd Streets, effectively on Hell’s Kitchen’s eastern edge. Walk west to Ninth or Tenth Avenue in 5–15 minutes. It is the practical arrival point for intercity and many New Jersey buses; do not pay for a cab merely to cross the avenue.